Cargando…

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Chronic lymphocytic leukaemia (CLL) cells can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear how these differences...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bryant, Dean, Smith, Lindsay, Rogers-Broadway, Karly Rai, Karydis, Laura, Woo, Jeongmin, Blunt, Matthew D., Forconi, Francesco, Stevenson, Freda K., Goodnow, Christopher, Russell, Amanda, Humburg, Peter, Packham, Graham, Steele, Andrew J., Strefford, Jonathan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317834/ https://www.ncbi.nlm.nih.gov/pubmed/37169950 http://dx.doi.org/10.1038/s41375-023-01918-9

Ejemplares similares

Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL
por: Heyman, B, et al.
Publicado: (2016)

Celebrating 20 Years of IGHV Mutation Analysis in CLL
por: Chiorazzi, Nicholas, et al.
Publicado: (2020)

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
por: Rigoni, Micol, et al.
Publicado: (2015)

Unmutated IGHV1-69 CLL Clone Displays a Distinct Gene Expression Profile by a Comparative qRT-PCR Assay
por: Mimmi, Selena, et al.
Publicado: (2022)

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells
por: Wilmore, Sarah, et al.
Publicado: (2021)

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia
por: Smith, Lindsay D., et al.
Publicado: (2019)

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2018)

Erratum: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2017)

Correction: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2019)

BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib
por: Bonfiglio, Silvia, et al.
Publicado: (2023)

Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease
por: Rose-Zerilli, M J J, et al.
Publicado: (2016)

Molecular Remission Using Low-Dose Immunotherapy with Minimal Toxicities for Poor Prognosis IGHV—Unmutated Chronic Lymphocytic Leukemia
por: Maharaj, Dipnarine, et al.
Publicado: (2020)

B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells
por: Taylor, Joe, et al.
Publicado: (2022)

High CXCR3 on Leukemic Cells Distinguishes IgHV(mut) from IgHV(unmut) in Chronic Lymphocytic Leukemia: Evidence from CD5(high) and CD5(low) Clones
por: Manukyan, Gayane, et al.
Publicado: (2020)

Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition
por: Pepper, C, et al.
Publicado: (2015)

Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV
por: Klausen, Uffe, et al.
Publicado: (2022)

P606: MEASUREMENT OF INTRACLONAL DIVERSIFICATION REFINES THE PROGNOSTIC IMPACT OF IGHV MUTATIONS IN CLL
por: Vit, Filippo, et al.
Publicado: (2023)

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells
por: Minton, Annabel R., et al.
Publicado: (2022)

Flow cytometry as a fast, cost-effective tool to assess IGHV mutational status in CLL
por: Couillez, Guillaume, et al.
Publicado: (2022)

Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia
por: Eagle, Gina L., et al.
Publicado: (2015)

Amplification efficiency and thermal stability of qPCR instrumentation: Current landscape and future perspectives
por: ROGERS-BROADWAY, KARLY-RAI, et al.
Publicado: (2015)

HLA specificities are associated with prognosis in IGHV-mutated CLL-like high-count monoclonal B cell lymphocytosis
por: García-Álvarez, María, et al.
Publicado: (2017)

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity
por: Sofou, Electra, et al.
Publicado: (2022)

Vom Unmut zum Zorn
por: Ruhaltinger, Josef
Publicado: (2023)

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
por: Linley, Adam J., et al.
Publicado: (2021)

Breiter Unmut über CERN-Ausstieg
Publicado: (2009)

Unmute the Organization Through Serious Play
por: Heldal, Frode, et al.
Publicado: (2021)

The morphology of CLL revisited: the clinical significance of prolymphocytes and correlations with prognostic/molecular markers in the LRF CLL4 trial
por: Oscier, David, et al.
Publicado: (2016)

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity
por: Valle-Argos, Beatriz, et al.
Publicado: (2021)

High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
por: Chiodin, Giorgia, et al.
Publicado: (2022)

Elucidating the role of DEPTOR in Alzheimer’s disease
por: DAVIES, JULIE, et al.
Publicado: (2014)

Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status
por: Shea, Lauren K., et al.
Publicado: (2019)

Variant B Cell Receptor Isotype Functions Differ in Hairy Cell Leukemia with Mutated BRAF and IGHV Genes
por: Weston-Bell, Nicola J., et al.
Publicado: (2014)

IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity
por: Avnir, Yuval, et al.
Publicado: (2016)

JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views
por: Gangat, Naseema, et al.
Publicado: (2021)

Erratum: IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity
por: Avnir, Yuval, et al.
Publicado: (2016)

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load
por: Hussmann, Dianna, et al.
Publicado: (2021)

Differential effects of rapalogues, dual kinase inhibitors on human ovarian carcinoma cells in vitro
por: ROGERS-BROADWAY, KARLY-RAI, et al.
Publicado: (2016)

New markers for murine memory B cells that define mutated and unmutated subsets
por: Anderson, Shannon M., et al.
Publicado: (2007)

Differential Requirement for Protein Synthesis in Presynaptic Unmuting and Muting in Hippocampal Glutamate Terminals
por: Crawford, Devon C., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4a2u4617b5i0uf6leukavdj1q1