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Synthesis and activity study of novel N,N-diphenylurea derivatives as IDO1 inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) has attracted much attention in the field of cancer immunotherapy as an immunomodulatory enzyme. To identify potential IDO1 inhibitors, a novel series of compounds with N,N-diphenylurea and triazole structures were synthesized. The designed compounds underwent or...

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Detalles Bibliográficos
Autores principales: Hou, Xi-Xi, Wu, Zi-Yuan, Zhan, An, Gao, En, Mao, Long-Fei, Wang, Hui-Li, Yang, Jian-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318132/
https://www.ncbi.nlm.nih.gov/pubmed/37408559
http://dx.doi.org/10.3389/fchem.2023.1222825