Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated...

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Detalles Bibliográficos
Autores principales: Tu, Teng, Zhang, Hongying, Xu, Huanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318190/
https://www.ncbi.nlm.nih.gov/pubmed/37409263
http://dx.doi.org/10.3389/fonc.2023.1197502
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author Tu, Teng
Zhang, Hongying
Xu, Huanji
author_facet Tu, Teng
Zhang, Hongying
Xu, Huanji
author_sort Tu, Teng
collection PubMed
description Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1.
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spelling pubmed-103181902023-07-05 Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy Tu, Teng Zhang, Hongying Xu, Huanji Front Oncol Oncology Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1. Frontiers Media S.A. 2023-06-20 /pmc/articles/PMC10318190/ /pubmed/37409263 http://dx.doi.org/10.3389/fonc.2023.1197502 Text en Copyright © 2023 Tu, Zhang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tu, Teng
Zhang, Hongying
Xu, Huanji
Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title_full Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title_fullStr Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title_full_unstemmed Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title_short Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
title_sort targeting sterol-o-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318190/
https://www.ncbi.nlm.nih.gov/pubmed/37409263
http://dx.doi.org/10.3389/fonc.2023.1197502
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