Modelling capture efficiency of single-cell RNA-sequencing data improves inference of transcriptome-wide burst kinetics

MOTIVATION: Gene expression is characterized by stochastic bursts of transcription that occur at brief and random periods of promoter activity. The kinetics of gene expression burstiness differs across the genome and is dependent on the promoter sequence, among other factors. Single-cell RNA sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Wenhao, Jørgensen, Andreas Christ Sølvsten, Marguerat, Samuel, Thomas, Philipp, Shahrezaei, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318389/
https://www.ncbi.nlm.nih.gov/pubmed/37354494
http://dx.doi.org/10.1093/bioinformatics/btad395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318389/
https://www.ncbi.nlm.nih.gov/pubmed/37354494
http://dx.doi.org/10.1093/bioinformatics/btad395

Ejemplares similares