Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation

AIMS: A key event in the regulation of cardiac contraction and relaxation is the phosphorylation of phospholamban (PLN) that relieves the inhibition of the sarco/endoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a). PLN exists in an equilibrium between monomers and pentamers. While only monomers can i...

Descripción completa

Detalles Bibliográficos
Autores principales: Funk, Florian, Kronenbitter, Annette, Hackert, Katarzyna, Oebbeke, Matthias, Klebe, Gerhard, Barth, Mareike, Koch, Daniel, Schmitt, Joachim P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318394/
https://www.ncbi.nlm.nih.gov/pubmed/36869774
http://dx.doi.org/10.1093/cvr/cvad037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318394/
https://www.ncbi.nlm.nih.gov/pubmed/36869774
http://dx.doi.org/10.1093/cvr/cvad037

Ejemplares similares