Cargando…

Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation

AIMS: A key event in the regulation of cardiac contraction and relaxation is the phosphorylation of phospholamban (PLN) that relieves the inhibition of the sarco/endoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a). PLN exists in an equilibrium between monomers and pentamers. While only monomers can i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Funk, Florian, Kronenbitter, Annette, Hackert, Katarzyna, Oebbeke, Matthias, Klebe, Gerhard, Barth, Mareike, Koch, Daniel, Schmitt, Joachim P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318394/ https://www.ncbi.nlm.nih.gov/pubmed/36869774 http://dx.doi.org/10.1093/cvr/cvad037

Ejemplares similares

Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers
por: Koch, Daniel, et al.
Publicado: (2021)

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
por: De Genst, Erwin, et al.
Publicado: (2022)

Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK (a) Shifts Mislead Popular Bioisosterism Concepts
por: Oebbeke, Matthias, et al.
Publicado: (2020)

Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses
por: Wienen‐Schmidt, Barbara, et al.
Publicado: (2020)

Synergistic Effects between Phosphorylation of Phospholamban and Troponin I Promote Relaxation at Higher Heart Rate
por: Zhang, Lin, et al.
Publicado: (2011)

Negative Adrenergic Feedback Specific to Phospholamban
por: Hasenfuss, Gerd, et al.
Publicado: (2017)

Levosimendan increases the phosphorylation state of phospholamban in the isolated human atrium
por: Abella, Lina Maria Rayo, et al.
Publicado: (2022)

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy
por: Kumar, Mohit, et al.
Publicado: (2023)

Prevalence and cardiac phenotype of patients with a phospholamban mutation
por: Hof, I. E., et al.
Publicado: (2018)

The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?
por: Heitner, Stephen B, et al.
Publicado: (2009)

Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors
por: Gergs, Ulrich, et al.
Publicado: (2019)

Structure-Function Relation of Phospholamban: Modulation of Channel Activity as a Potential Regulator of SERCA Activity
por: Smeazzetto, Serena, et al.
Publicado: (2013)

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation
por: Lefebvre, Solène N, et al.
Publicado: (2021)

Immunoelectron microscopical localization of phospholamban in adult canine ventricular muscle
Publicado: (1987)

Localization of phospholamban in smooth muscle using immunogold electron microscopy
Publicado: (1988)

The role of CaMKII regulation of phospholamban activity in heart disease
por: Mattiazzi, Alicia, et al.
Publicado: (2014)

Phospholamban cardiomyopathy: a Canadian perspective on a unique population
por: Cheung, C. C., et al.
Publicado: (2019)

Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes
por: Mundiña-Weilenmann, Cecilia Beatriz, et al.
Publicado: (2019)

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
por: Grote Beverborg, Niels, et al.
Publicado: (2021)

Phospholamban R14del disease: The past, the present and the future
por: Vafiadaki, Elizabeth, et al.
Publicado: (2023)

The Pentameric Channel of COMPcc in Complex with Different Fatty Acids
por: MacFarlane, Ainsley A., et al.
Publicado: (2012)

Protein dynamics and the allosteric transitions of pentameric receptor channels
por: Changeux, Jean-Pierre
Publicado: (2014)

Pentameric assembly of the Kv2.1 tetramerization domain
por: Xu, Zhen, et al.
Publicado: (2022)

Obesity does not Lead to Imbalance Between Myocardial Phospholamban Phosphorylation and Dephosphorylation
por: Freire, Paula Paccielli, et al.
Publicado: (2014)

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
por: Fajardo, Val A., et al.
Publicado: (2015)

Atomistic Structure and Dynamics of the Ca(2+)-ATPase Bound to Phosphorylated Phospholamban
por: Aguayo-Ortiz, Rodrigo, et al.
Publicado: (2020)

Rationale and design of the PHOspholamban RElated CArdiomyopathy intervention STudy (i-PHORECAST)
por: te Rijdt, W. P., et al.
Publicado: (2021)

Production of Pentameric Cholera Toxin B Subunit in Escherichia coli
por: Dakterzada, Farida, et al.
Publicado: (2012)

Recognition Functions of Pentameric C-Reactive Protein in Cardiovascular Disease
por: Agrawal, Alok, et al.
Publicado: (2014)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Early Cambrian Pentamerous Cubozoan Embryos from South China
por: Han, Jian, et al.
Publicado: (2013)

Correction: The Pentameric Channel of COMPcc in Complex with Different Fatty Acids
por: McFarlane, Ainsley, et al.
Publicado: (2013)

Hexameric and pentameric complexes of the ExbBD energizer in the Ton system
por: Maki-Yonekura, Saori, et al.
Publicado: (2018)

Effect of pressure on refolding of recombinant pentameric cholera toxin B
por: Rodrigues, D., et al.
Publicado: (2014)

Asymmetric gating of a human hetero-pentameric glycine receptor
por: Liu, Xiaofen, et al.
Publicado: (2023)

Asymmetric gating of a human hetero-pentameric glycine receptor
por: Liu, Xiaofen, et al.
Publicado: (2023)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers
por: Fajardo, Val A., et al.
Publicado: (2013)

Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function
por: Keceli, Gizem, et al.
Publicado: (2019)

Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice
por: Fajardo, Val A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f95v0c00s446ou033uar86pkr1