Design, synthesis and antitumor activity of Ascaphin-8 derived stapled peptides based on halogen–sulfhydryl click chemical reactions

Ascaphin-8 (GFKDLLKGAAKALVKTVLF-NH(2)), isolated from the norepinephrine-stimulated skin secretion of the North American-tailed frog Ascaphus truei, is a C-terminal α-helical antimicrobial peptide with potential antitumor activity. However, linear peptides are difficult to be applied directly as dru...

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Detalles Bibliográficos
Autores principales: Kong, Xianglong, Zhang, Nan, Shen, Huaxing, Wang, Nan, Cong, Wei, Liu, Chao, Hu, Hong-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318414/
https://www.ncbi.nlm.nih.gov/pubmed/37409042
http://dx.doi.org/10.1039/d3ra02743k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318414/
https://www.ncbi.nlm.nih.gov/pubmed/37409042
http://dx.doi.org/10.1039/d3ra02743k

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