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Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in C. elegans
Meiotic crossovers promote accurate chromosome segregation during gametogenesis. In C. elegans , a highly conserved AAA ATPase, PCH-2, ensures that homologous chromosomes have at least one crossover, preventing meiotic defects. PCH-2 localizes to meiotic chromosomes and this localization is extended...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318441/ https://www.ncbi.nlm.nih.gov/pubmed/37408786 http://dx.doi.org/10.17912/micropub.biology.000839 |
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author | Patel, Bhumil Grobler, Maryke Bhalla, Needhi |
author_facet | Patel, Bhumil Grobler, Maryke Bhalla, Needhi |
author_sort | Patel, Bhumil |
collection | PubMed |
description | Meiotic crossovers promote accurate chromosome segregation during gametogenesis. In C. elegans , a highly conserved AAA ATPase, PCH-2, ensures that homologous chromosomes have at least one crossover, preventing meiotic defects. PCH-2 localizes to meiotic chromosomes and this localization is extended when there are defects in meiotic recombination, suggesting a role in responding to defects. Here, we show that, unlike in other systems, PCH-2 does not persist on meiotic chromosomes when there are chromosomal inversions but does persist when there are whole chromosome fusions. Moreover, this persistence correlates with an increase in crossovers, demonstrating that PCH-2’s localization to chromosomes promotes crossover formation. |
format | Online Article Text |
id | pubmed-10318441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-103184412023-07-05 Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in C. elegans Patel, Bhumil Grobler, Maryke Bhalla, Needhi MicroPubl Biol New Finding Meiotic crossovers promote accurate chromosome segregation during gametogenesis. In C. elegans , a highly conserved AAA ATPase, PCH-2, ensures that homologous chromosomes have at least one crossover, preventing meiotic defects. PCH-2 localizes to meiotic chromosomes and this localization is extended when there are defects in meiotic recombination, suggesting a role in responding to defects. Here, we show that, unlike in other systems, PCH-2 does not persist on meiotic chromosomes when there are chromosomal inversions but does persist when there are whole chromosome fusions. Moreover, this persistence correlates with an increase in crossovers, demonstrating that PCH-2’s localization to chromosomes promotes crossover formation. Caltech Library 2023-06-19 /pmc/articles/PMC10318441/ /pubmed/37408786 http://dx.doi.org/10.17912/micropub.biology.000839 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Patel, Bhumil Grobler, Maryke Bhalla, Needhi Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in C. elegans |
title |
Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in
C. elegans
|
title_full |
Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in
C. elegans
|
title_fullStr |
Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in
C. elegans
|
title_full_unstemmed |
Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in
C. elegans
|
title_short |
Chromosomal fusions, but not chromosomal inversions, activate a PCH-2 dependent checkpoint that promotes crossover formation in
C. elegans
|
title_sort | chromosomal fusions, but not chromosomal inversions, activate a pch-2 dependent checkpoint that promotes crossover formation in
c. elegans |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318441/ https://www.ncbi.nlm.nih.gov/pubmed/37408786 http://dx.doi.org/10.17912/micropub.biology.000839 |
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