Selective inhibitors of the PSEN1–gamma-secretase complex

Clinical development of γ-secretases, a family of intramembrane cleaving proteases, as therapeutic targets for a variety of disorders including cancer and Alzheimer’s disease was aborted because of serious mechanism-based side effects in the phase III trials of unselective inhibitors. Selective inhi...

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Detalles Bibliográficos
Autores principales: Serneels, Lutgarde, Narlawar, Rajeshwar, Perez-Benito, Laura, Municoy, Marti, Guallar, Victor, T’Syen, Dries, Dewilde, Maarten, Bischoff, François, Fraiponts, Erwin, Tresadern, Gary, Roevens, Peter W.M., Gijsen, Harrie J.M., De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318456/
https://www.ncbi.nlm.nih.gov/pubmed/37164155
http://dx.doi.org/10.1016/j.jbc.2023.104794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318456/
https://www.ncbi.nlm.nih.gov/pubmed/37164155
http://dx.doi.org/10.1016/j.jbc.2023.104794

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