The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection

Sterile alpha motif and histidine-aspartate (HD) domain–containing protein 1 (SAMHD1) inhibits HIV-1 replication in nondividing cells by reducing the intracellular dNTP pool. SAMHD1 also suppresses NF-κB activation induced by inflammatory stimuli and viral infections. Specifically, SAMHD1-mediated r...

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Detalles Bibliográficos
Autores principales: Yang, Hua, Espada, Constanza E., Phillips, Stacia, Martinez, Nicholas, Kenney, Adam D., Yount, Jacob S., Xiong, Yong, Wu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318468/
https://www.ncbi.nlm.nih.gov/pubmed/37100289
http://dx.doi.org/10.1016/j.jbc.2023.104750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318468/
https://www.ncbi.nlm.nih.gov/pubmed/37100289
http://dx.doi.org/10.1016/j.jbc.2023.104750

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