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A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism
Congenital hyperinsulinism (HI), a beta cell disorder most commonly caused by inactivating mutations of beta cell K(ATP) channels, results in dysregulated insulin secretion and persistent hypoglycemia. Children with K(ATP)-HI are unresponsive to diazoxide, the only FDA-approved drug for HI, and util...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318504/ https://www.ncbi.nlm.nih.gov/pubmed/37178920 http://dx.doi.org/10.1016/j.jbc.2023.104816 |