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A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism

Congenital hyperinsulinism (HI), a beta cell disorder most commonly caused by inactivating mutations of beta cell K(ATP) channels, results in dysregulated insulin secretion and persistent hypoglycemia. Children with K(ATP)-HI are unresponsive to diazoxide, the only FDA-approved drug for HI, and util...

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Detalles Bibliográficos
Autores principales:	Juliana, Christine A., Chai, Jinghua, Arroyo, Pablo, Rico-Bautista, Elizabeth, Betz, Stephen F., De León, Diva D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318504/ https://www.ncbi.nlm.nih.gov/pubmed/37178920 http://dx.doi.org/10.1016/j.jbc.2023.104816

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