Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits

Capsaicin receptor TRPV1 is a nociceptor for vanilloid molecules, such as capsaicin and resiniferatoxin (RTX). Even though cryo-EM structures of TRPV1 in complex with these molecules are available, how their binding energetically favors the open conformation is not known. Here, we report an approach...

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Detalles Bibliográficos
Autores principales: Li, Shisheng, Nguyen, Phuong T., Vu, Simon, Yarov-Yarovoy, Vladimir, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318505/
https://www.ncbi.nlm.nih.gov/pubmed/37196769
http://dx.doi.org/10.1016/j.jbc.2023.104828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318505/
https://www.ncbi.nlm.nih.gov/pubmed/37196769
http://dx.doi.org/10.1016/j.jbc.2023.104828

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