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IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer
Regulated tryptophan metabolism by immune cells has been associated with the promotion of tolerance and poor outcomes in cancer. The main focus of research has centered on local tryptophan depletion by IDO1, an intracellular heme-dependent oxidase that converts tryptophan to formyl-kynurenine. This...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318530/ https://www.ncbi.nlm.nih.gov/pubmed/37196768 http://dx.doi.org/10.1016/j.jbc.2023.104827 |