IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation

In chronic infections and cancer, exhausted CD8 T cells exhibit heterogeneous subpopulations. TCF1+PD-1+ progenitor exhausted CD8 T cells (Tpex) can self-renew and give rise to Tim-3+PD-1+ terminally differentiated CD8 T cells that retain their effector functions. Tpex cells are thus essential to ma...

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Detalles Bibliográficos
Autores principales: Lee, Junghwa, Lee, Kyungmin, Bae, Hyeonjin, Lee, Kunhee, Lee, Solhwi, Ma, Junhui, Jo, Kyungjo, Kim, Ijun, Jee, ByulA, Kang, Minyong, Im, Se Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319055/
https://www.ncbi.nlm.nih.gov/pubmed/37409128
http://dx.doi.org/10.3389/fimmu.2023.1117092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319055/
https://www.ncbi.nlm.nih.gov/pubmed/37409128
http://dx.doi.org/10.3389/fimmu.2023.1117092

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