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Protocol to analyze endogenous translesion DNA synthesis in single mammalian cells

Translesion DNA synthesis (TLS) is an evolutionarily conserved branch of the cellular DNA damage tolerance pathway that is often exploited by cancer cells to overcome therapy resistance. Here, we present a protocol to analyze endogenous TLS in single mammalian cells in the absence or presence of DNA...

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Detalles Bibliográficos
Autores principales: Egger, Tom, Aze, Antoine, Maiorano, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319309/
https://www.ncbi.nlm.nih.gov/pubmed/37355992
http://dx.doi.org/10.1016/j.xpro.2023.102361