Ketamine’s rapid antidepressant effects are mediated by Ca(2+)-permeable AMPA receptors

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is presumed to underlie its rapid antidepressant effects. Moreover, ketamine’s therapeutic actions are likely mediated by enhancing neuronal Ca(2+) signaling. However, ketamine is a noncompetitive NMDA receptor (NM...

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Detalles Bibliográficos
Autores principales: Zaytseva, Anastasiya, Bouckova, Evelina, Wiles, McKennon J, Wustrau, Madison H, Schmidt, Isabella G, Mendez-Vazquez, Hadassah, Khatri, Latika, Kim, Seonil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319435/
https://www.ncbi.nlm.nih.gov/pubmed/37358072
http://dx.doi.org/10.7554/eLife.86022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319435/
https://www.ncbi.nlm.nih.gov/pubmed/37358072
http://dx.doi.org/10.7554/eLife.86022

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