Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circuitry and synaptic loss. Microglia and peripheral inn...

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Detalles Bibliográficos
Autores principales: Gasser, Julien, Gillet, Gaelle, Valadas, Jorge S., Rouvière, Laura, Kotian, Apoorva, Fan, Wenqiang, Keaney, James, Kadiu, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319581/
https://www.ncbi.nlm.nih.gov/pubmed/37415834
http://dx.doi.org/10.3389/fnmol.2023.1191324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319581/
https://www.ncbi.nlm.nih.gov/pubmed/37415834
http://dx.doi.org/10.3389/fnmol.2023.1191324

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