Cyclic anthraquinone derivatives, unique G-quadruplex binders, selectively induce cancer cell apoptosis and inhibit tumor growth

Cyclic anthraquinone derivatives (cAQs), which link two side chains of 1,5-disubstituted anthraquinone as a threading DNA intercalator, have been developed as G-quartet (G4) DNA-specific ligands. Among the cAQs, cAQ-mBen linked through the 1,3-position of benzene had the strongest affinity for G4 re...

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Detalles Bibliográficos
Autores principales: Fukuda, Hikaru, Zou, Tingting, Fujii, Satoshi, Sato, Shinobu, Wakahara, Daiki, Higashi, Sen, Tseng, Ting-Yuan, Chang, Ta-Chau, Yada, Naomi, Matsuo, Kou, Habu, Manabu, Tominaga, Kazuhiro, Takeuchi, Hiroshi, Takenaka, Shigeori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Physical Sciences and Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319625/
https://www.ncbi.nlm.nih.gov/pubmed/37416876
http://dx.doi.org/10.1093/pnasnexus/pgad211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319625/
https://www.ncbi.nlm.nih.gov/pubmed/37416876
http://dx.doi.org/10.1093/pnasnexus/pgad211

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