Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

BACKGROUND: Experimental data show that drug-resistance-conferring mutations are often associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitness cost can be mitigated by compensatory mutations; however, the role of compensatory evolution in clinical settings i...

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Detalles Bibliográficos
Autores principales: Goig, Galo A, Menardo, Fabrizio, Salaam-Dreyer, Zubeida, Dippenaar, Anzaan, Streicher, Elizabeth M, Daniels, Johnny, Reuter, Anja, Borrell, Sonia, Reinhard, Miriam, Doetsch, Anna, Beisel, Christian, Warren, Robin M, Cox, Helen, Gagneux, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319636/
https://www.ncbi.nlm.nih.gov/pubmed/37295446
http://dx.doi.org/10.1016/S2666-5247(23)00110-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319636/
https://www.ncbi.nlm.nih.gov/pubmed/37295446
http://dx.doi.org/10.1016/S2666-5247(23)00110-6

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