In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir

Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is clinically useful against infection with SARS-CoV-2 including its omicron variants. Since most omicron subvariants have reduced sensitivity to many monoclonal antibody therapies, potential SARS-CoV-2 resistanc...

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Detalles Bibliográficos
Autores principales: Kiso, Maki, Furusawa, Yuri, Uraki, Ryuta, Imai, Masaki, Yamayoshi, Seiya, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319741/
https://www.ncbi.nlm.nih.gov/pubmed/37402789
http://dx.doi.org/10.1038/s41467-023-39704-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319741/
https://www.ncbi.nlm.nih.gov/pubmed/37402789
http://dx.doi.org/10.1038/s41467-023-39704-x

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