Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro has required the addition of polyanions or other co-factors to induce its misfolding and aggregation, with hepa...

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Detalles Bibliográficos
Autores principales: Limorenko, Galina, Tatli, Meltem, Kolla, Rajasekhar, Nazarov, Sergey, Weil, Marie-Theres, Schöndorf, David C., Geist, Daniela, Reinhardt, Peter, Ehrnhoefer, Dagmar E., Stahlberg, Henning, Gasparini, Laura, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319797/
https://www.ncbi.nlm.nih.gov/pubmed/37402718
http://dx.doi.org/10.1038/s41467-023-39314-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319797/
https://www.ncbi.nlm.nih.gov/pubmed/37402718
http://dx.doi.org/10.1038/s41467-023-39314-7

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