ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo

ARL-17477 is a selective neuronal nitric oxide synthase (NOS1) inhibitor that has been used in many preclinical studies since its initial discovery in the 1990s. In the present study, we demonstrate that ARL-17477 exhibits a NOS1-independent pharmacological activity that involves inhibition of the a...

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Detalles Bibliográficos
Autores principales: Nomura, Teiko Komori, Endo, Satoshi, Kuwano, Takuma, Fukasawa, Kazuya, Takashima, Shigeo, Todo, Tomoki, Furuta, Kyoji, Yamamoto, Takuhei, Hinoi, Eiichi, Koyama, Hiroko, Honda, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319805/
https://www.ncbi.nlm.nih.gov/pubmed/37402770
http://dx.doi.org/10.1038/s41598-023-37797-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319805/
https://www.ncbi.nlm.nih.gov/pubmed/37402770
http://dx.doi.org/10.1038/s41598-023-37797-4

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