Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~ 43,800) of SK-BMD, identifying 59 loci, collective...

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Detalles Bibliográficos
Autores principales: Medina-Gomez, Carolina, Mullin, Benjamin H., Chesi, Alessandra, Prijatelj, Vid, Kemp, John P., Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E., Schraut, Katharina E., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Zillikens, M. Carola, Zhu, Kun, Mook-Kanamori, Dennis O., Evans, Daniel S., Nethander, Maria, Knol, Maria J., Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E., van Schoor, Natasja M., Reppe, Sjur, Pawlak, Mikolaj A., Ralston, Stuart H., van der Velde, Nathalie, Lorentzon, Mattias, Stefansson, Kari, Adams, Hieab H. H., Wilson, Scott G., Ikram, M. Arfan, Walsh, John P., Lakka, Timo A., Gautvik, Kaare M., Wilson, James F., Orwoll, Eric S., van Duijn, Cornelia M., Bønnelykke, Klaus, Uitterlinden, Andre G., Styrkársdóttir, Unnur, Akesson, Kristina E., Spector, Timothy D., Tobias, Jonathan H., Ohlsson, Claes, Felix, Janine F., Bisgaard, Hans, Grant, Struan F. A., Richards, J. Brent, Evans, David M., van der Eerden, Bram, van de Peppel, Jeroen, Ackert-Bicknell, Cheryl, Karasik, David, Kague, Erika, Rivadeneira, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319806/
https://www.ncbi.nlm.nih.gov/pubmed/37402774
http://dx.doi.org/10.1038/s42003-023-04869-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319806/
https://www.ncbi.nlm.nih.gov/pubmed/37402774
http://dx.doi.org/10.1038/s42003-023-04869-0

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