Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance in vivo. Here we show that acute dosing of UCN2 induces systemic insulin resistance in male...

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Detalles Bibliográficos
Autores principales: Flaherty, Stephen E., Bezy, Olivier, Zheng, Wei, Yan, Dong, Li, Xiangping, Jagarlapudi, Srinath, Albuquerque, Bina, Esquejo, Ryan M., Peloquin, Matthew, Semache, Meriem, Mancini, Arturo, Kang, Liya, Drujan, Doreen, Breitkopf, Susanne B., Griffin, John D., Jean Beltran, Pierre M., Xue, Liang, Stansfield, John, Pashos, Evanthia, Shakey, Quazi, Pehmøller, Christian, Monetti, Mara, Birnbaum, Morris J., Fortin, Jean-Philippe, Wu, Zhidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319809/
https://www.ncbi.nlm.nih.gov/pubmed/37402735
http://dx.doi.org/10.1038/s41467-023-39597-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319809/
https://www.ncbi.nlm.nih.gov/pubmed/37402735
http://dx.doi.org/10.1038/s41467-023-39597-w

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