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Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF

We performed scRNA-seq/snATAC-seq of skeletal muscles post sciatic nerve transection to delineate cell type-specific patterns of gene expression/chromatin accessibility at different time points post-denervation. Unlike myotrauma, denervation selectively activates glial cells and Thy1/CD90-expressing...

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Detalles Bibliográficos
Autores principales: Nicoletti, Chiara, Wei, Xiuqing, Etxaniz, Usue, D’Ercole, Chiara, Madaro, Luca, Perera, Ranjan, Puri, Pier Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319848/
https://www.ncbi.nlm.nih.gov/pubmed/37416457
http://dx.doi.org/10.1016/j.isci.2023.107114