Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study

BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including cancers. BRD4 is a well-studied target, and many chemical scaffolds for inhibitors have been...

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Detalles Bibliográficos
Autores principales: Kim, Jung-Hoon, Pandit, Navin, Yoo, Miyoun, Park, Tae Hyun, Choi, Ji U, Park, Chi Hoon, Jung, Kwan-Young, Lee, Byung Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319850/
https://www.ncbi.nlm.nih.gov/pubmed/37402749
http://dx.doi.org/10.1038/s41598-023-37527-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319850/
https://www.ncbi.nlm.nih.gov/pubmed/37402749
http://dx.doi.org/10.1038/s41598-023-37527-w

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