Single cohesin molecules generate force by two distinct mechanisms

Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA and extrude DNA loops. How cohesin works mechanistically as a molecular machine is poorly understood. Here, we measure mechanical forces generated by conformational changes in single cohesin molecules. We show t...

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Detalles Bibliográficos
Autores principales: Pobegalov, Georgii, Chu, Lee-Ya, Peters, Jan-Michael, Molodtsov, Maxim I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319895/
https://www.ncbi.nlm.nih.gov/pubmed/37402740
http://dx.doi.org/10.1038/s41467-023-39696-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319895/
https://www.ncbi.nlm.nih.gov/pubmed/37402740
http://dx.doi.org/10.1038/s41467-023-39696-8

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