Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of pulmonary fibrosis (PF). However, the exact mechanism underlying AEC senescence during PF remains poorly understood. Here, we reported an unrecognized mechanism for AEC senescence during PF. We found that, in bleomycin (B...

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Detalles Bibliográficos
Autores principales: Hong, Jie-Ru, Jin, Ling, Zhang, Chen-Yu, Zhong, Wen-Jing, Yang, Hui-Hui, Wang, Guan-Ming, Ma, Sheng-Chao, Guan, Cha-Xiang, Li, Qing, Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320039/
https://www.ncbi.nlm.nih.gov/pubmed/37416635
http://dx.doi.org/10.1016/j.heliyon.2023.e17361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320039/
https://www.ncbi.nlm.nih.gov/pubmed/37416635
http://dx.doi.org/10.1016/j.heliyon.2023.e17361

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