CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation

The transcription factor Interferon regulatory factor 8 (IRF8) is involved in maintaining B cell identity. However, how IRF8 regulates T cell independent B cell responses are not fully characterized. Here, an in vivo CRISPR/Cas9 system was optimized to generate Irf8-deficient murine B cells and used...

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Detalles Bibliográficos
Autores principales: Zuo, Zhihong, Kania, Anna K., Patterson, Dillon G., Hicks, Sakeenah L., Maurer, Jeffrey, Gupta, Mansi, Boss, Jeremy M., Scharer, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320122/
https://www.ncbi.nlm.nih.gov/pubmed/37416674
http://dx.doi.org/10.1016/j.heliyon.2023.e17527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320122/
https://www.ncbi.nlm.nih.gov/pubmed/37416674
http://dx.doi.org/10.1016/j.heliyon.2023.e17527

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