GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the γ-secretase complex

Despite recent advances in research, the mechanism of Alzheimer's disease is not fully understood yet. Understanding the process of cleavage and then trimming of peptide substrates, can help selectively block γ-secretase (GS) to stop overproduction of the amyloidogenic products. Our GS-SMD serv...

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Detalles Bibliográficos
Autores principales: Orzeł, Urszula, Pasznik, Paweł, Miszta, Przemysław, Lorkowski, Marcin, Niewieczerzał, Szymon, Jakowiecki, Jakub, Filipek, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Web Server Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320170/
https://www.ncbi.nlm.nih.gov/pubmed/37207343
http://dx.doi.org/10.1093/nar/gkad409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320170/
https://www.ncbi.nlm.nih.gov/pubmed/37207343
http://dx.doi.org/10.1093/nar/gkad409

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