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GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the γ-secretase complex
Despite recent advances in research, the mechanism of Alzheimer's disease is not fully understood yet. Understanding the process of cleavage and then trimming of peptide substrates, can help selectively block γ-secretase (GS) to stop overproduction of the amyloidogenic products. Our GS-SMD serv...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320170/ https://www.ncbi.nlm.nih.gov/pubmed/37207343 http://dx.doi.org/10.1093/nar/gkad409 |