Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response

TREX1 encodes a major DNA exonuclease and mutations of this gene are associated with type I interferonopathies in human. Mice with Trex1 deletion or mutation have shortened life spans accompanied by a senescence-associated secretory phenotype. However, the contribution of cellular senescence in TREX...

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Detalles Bibliográficos
Autores principales: Du, Hekang, Xiao, Nanyang, Zhang, Sitong, Zhou, Xueyuan, Zhang, Yangfan, Lu, Zengzeng, Fu, Yuqian, Huang, Miaohui, Xu, Shan, Chen, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320204/
https://www.ncbi.nlm.nih.gov/pubmed/37416470
http://dx.doi.org/10.1016/j.isci.2023.107090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320204/
https://www.ncbi.nlm.nih.gov/pubmed/37416470
http://dx.doi.org/10.1016/j.isci.2023.107090

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