An Oncolytic Poxvirus Encoding hNIS, Shows Antitumor Efficacy and Allows Tumor Imaging in a Liver Cancer Model

Oncolytic viruses (OV) are live viruses that can selectively replicate in cancer cells. We have engineered an OV (CF33) to make it cancer-selective through the deletion of its J2R (thymidine kinase) gene. In addition, this virus has been armed with a reporter gene, human sodium iodide symporter (hNI...

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Detalles Bibliográficos
Autores principales: Chaurasiya, Shyambabu, Valencia, Hannah, Zhang, Zhifang, Kim, Sang-In, Yang, Annie, Lu, Jianming, Woo, Yanghee, Warner, Susanne G., Ede, Nicholas J., Fong, Yuman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Models and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320468/
http://dx.doi.org/10.1158/1535-7163.MCT-22-0635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320468/
http://dx.doi.org/10.1158/1535-7163.MCT-22-0635

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