RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer

PURPOSE: To determine the ability of RAD51 foci to predict platinum chemotherapy response in high-grade serous ovarian cancer (HGSOC) patient-derived samples. EXPERIMENTAL DESIGN: RAD51 and γH2AX nuclear foci were evaluated by immunofluorescence in HGSOC patient-derived cell lines (n = 5), organoids...

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Detalles Bibliográficos
Autores principales: Compadre, Amanda J., van Biljon, Lillian N., Valentine, Mark C., Llop-Guevara, Alba, Graham, Emily, Fashemi, Bisiayo, Herencia-Ropero, Andrea, Kotnik, Emilee N., Cooper, Isaac, Harrington, Shariska P., Kuroki, Lindsay M., McCourt, Carolyn K., Hagemann, Andrea R., Thaker, Premal H., Mutch, David G., Powell, Matthew A., Sun, Lulu, Mosammaparast, Nima, Serra, Violeta, Zhao, Peinan, Lomonosova, Elena, Khabele, Dineo, Mullen, Mary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320470/
https://www.ncbi.nlm.nih.gov/pubmed/37097615
http://dx.doi.org/10.1158/1078-0432.CCR-22-3335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320470/
https://www.ncbi.nlm.nih.gov/pubmed/37097615
http://dx.doi.org/10.1158/1078-0432.CCR-22-3335

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