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Pharmacologic inhibition of glycolysis prevents the development of lupus by altering the gut microbiome in mice
Gut dysbiosis has been associated with lupus pathogenesis, and fecal microbiota transfers (FMT) from lupus-prone mice shown to induce autoimmune activation into healthy mice. The immune cells of lupus patients exhibit an increased glucose metabolism and treatments with 2-deoxy-D-glucose (2DG), a gly...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320500/ https://www.ncbi.nlm.nih.gov/pubmed/37416482 http://dx.doi.org/10.1016/j.isci.2023.107122 |