A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences

The current understanding of farnesyltransferase (FTase) specificity was pioneered through investigations of reporters like Ras and Ras-related proteins that possess a C-terminal CaaX motif that consists of 4 amino acid residues: cysteine–aliphatic(1)–aliphatic(2)–variable (X). These studies led to...

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Detalles Bibliográficos
Autores principales: Kim, June H, Hildebrandt, Emily R, Sarkar, Anushka, Yeung, Wayland, Waldon, La Ryel A, Kannan, Natarajan, Schmidt, Walter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320760/
https://www.ncbi.nlm.nih.gov/pubmed/37119806
http://dx.doi.org/10.1093/g3journal/jkad094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320760/
https://www.ncbi.nlm.nih.gov/pubmed/37119806
http://dx.doi.org/10.1093/g3journal/jkad094

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