Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis

In some organisms, the replication of G-quadruplex (G4) structures is supported by the Rev1 DNA polymerase. We previously showed that residues in the insert-2 motif of human Rev1 (hRev1) increased the affinity of the enzyme for G4 DNA and mediated suppression of mutagenic replication near G4 motifs....

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Detalles Bibliográficos
Autores principales: Ketkar, Amit, Sewilam, Reham S., McCrury, Mason J., Hall, Jaycelyn S., Bell, Ashtyn, Paxton, Bethany C., Tripathi, Shreyam, Gunderson, Julie E.C., Eoff, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320842/
https://www.ncbi.nlm.nih.gov/pubmed/37415867
http://dx.doi.org/10.1039/d3cb00027c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320842/
https://www.ncbi.nlm.nih.gov/pubmed/37415867
http://dx.doi.org/10.1039/d3cb00027c

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