Cargando…

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome

INTRODUCTION: Blau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by a mutation in the NOD2 gene. It is characterized by a clinical trial of granulomatous dermatitis, arthritis, and uveitis. Tofacitinib is a pan Janus kinase (JAK) inhibitor used for treatment of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ueki, Yoko, Takimoto-Ito, Riko, Saito, Megumu K., Tanizaki, Hideaki, Kambe, Naotomo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321295/ https://www.ncbi.nlm.nih.gov/pubmed/37415984 http://dx.doi.org/10.3389/fimmu.2023.1211240

Ejemplares similares

Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis
por: Matsuda, Tomoko, et al.
Publicado: (2022)

NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination
por: Arakawa, Akiko, et al.
Publicado: (2021)

Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin
por: Kishimoto, Izumi, et al.
Publicado: (2022)

Incomplete penetrance of NOD2 C483W mutation underlining Blau syndrome
por: Chang, Shao-Yu, et al.
Publicado: (2022)

The Potential Role of Basophils in Urticaria
por: Takimoto-Ito, Riko, et al.
Publicado: (2022)

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function
por: Mao, Liming, et al.
Publicado: (2022)

NOD2 mosaicism in Blau syndrome
por: Mensa-Vilaro, A, et al.
Publicado: (2015)

Case Report: Methotrexate and hydroxychloroquine in combination for the treatment of NOD2-mutation-associated Blau syndrome
por: Jensen, Mary Ellen, et al.
Publicado: (2023)

Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations
por: Nishiyama, Mizuho, et al.
Publicado: (2021)

Tofacitinib effectiveness in Blau syndrome: a case series of Chinese paediatric patients
por: Zhang, Song, et al.
Publicado: (2021)

Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome
por: Ikeda, Kei, et al.
Publicado: (2014)

Emperipolesis and cell death in NOD2-related Blau Syndrome and Crohn’s disease
por: Janssen, Carl EI, et al.
Publicado: (2011)

Clinical and immunological study of Tofacitinib and Baricitinib in refractory Blau syndrome: case report and literature review
por: Álvarez-Reguera, Carmen, et al.
Publicado: (2022)

A Novel Mutation in Helical Domain 2 of NOD2 in Sporadic Blau Syndrome
por: Jain, Lubhani, et al.
Publicado: (2016)

NOD2/CARD15 gene mutation identified in a Chinese family with Blau syndrome
por: Xiang, Haotian, et al.
Publicado: (2012)

A familial case of Blau syndrome caused by a novel NOD2 genetic mutation
por: Kim, Woojoong, et al.
Publicado: (2016)

Blau syndrome: Lessons learned in a tertiary care centre at Chandigarh, North India
por: Kumrah, Rajni, et al.
Publicado: (2022)

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators
por: Parkhouse, Rhiannon, et al.
Publicado: (2014)

Blau Syndrome-Related CARD15/NOD2 Mutations Are Not Linked to Idiopathic Uveitis in Spanish Patients
por: Rodríguez-Pérez, Noelia, et al.
Publicado: (2009)

PReS-FINAL-2201: A P268S NOD mutation in one Blau patient
por: Pardeo, M, et al.
Publicado: (2013)

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis
por: Iwasaki, Tomoyuki, et al.
Publicado: (2016)

A Case of Blau Syndrome
por: Chauhan, Krati, et al.
Publicado: (2014)

P03-012 - A P268S NOD2 mutation in one Blau patient
por: Pardeo, M, et al.
Publicado: (2013)

Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease
por: Caso, Francesco, et al.
Publicado: (2015)

Sinus of valsalva aneurysm in Blau's syndrome
por: Mourad, Faisal, et al.
Publicado: (2010)

Identification of Blau Syndrome disease signatures
por: Foley, KP, et al.
Publicado: (2011)

A New Mutation in Blau Syndrome
por: Zeybek, Cengiz, et al.
Publicado: (2015)

Aortoarteritis and cardiomyopathy in a child with Blau Syndrome
por: Khubchandani, RP, et al.
Publicado: (2011)

65. Blau syndrome treated with sequential biologics
por: Yi Yong, Cee, et al.
Publicado: (2018)

72. A retrospective diagnosis of Blau syndrome
por: Ellis, Jessica, et al.
Publicado: (2018)

Blau syndrome: An under-reported condition in India?
por: Agarwal, A, et al.
Publicado: (2022)

Co-existence of Blau syndrome and NAID? Diagnostic challenges associated with presence of multiple pathogenic variants in NOD2 gene: a case report
por: Dziedzic, Magdalena, et al.
Publicado: (2017)

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
por: Nakamura, Yuumi, et al.
Publicado: (2009)

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
por: Nakamura, Yuumi, et al.
Publicado: (2009)

Blau Syndrome, the prototypic auto-inflammatory granulomatous disease
por: Wouters, Carine H, et al.
Publicado: (2014)

A new mutation in blau syndrome: case report
por: Zeybek, Cengiz, et al.
Publicado: (2014)

EP25 Blau syndrome: a lifetime of sarcoid
por: Chauhan, Neal, et al.
Publicado: (2020)

Blau syndrome: a case report from Palestine
por: Iriqat, Salam, et al.
Publicado: (2021)

NOD1 and NOD2 Signaling in Infection and Inflammation
por: Moreira, Lilian O., et al.
Publicado: (2012)

Detection of Mycobacterium avium ss. Paratuberculosis in Blau Syndrome Tissues
por: Dow, C. Thomas, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6f69csra566bu43dj207b51bin