High-throughput screen with the l,d-transpeptidase Ldt(Mt2) of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

Disruption of bacterial cell wall biosynthesis in Mycobacterium tuberculosis is a promising target for treating tuberculosis. The l,d-transpeptidase Ldt(Mt2), which is responsible for the formation of 3 → 3 cross-links in the cell wall peptidoglycan, has been identified as essential for M. tuberculo...

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Detalles Bibliográficos
Autores principales: de Munnik, Mariska, Lang, Pauline A., De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H., Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321483/
https://www.ncbi.nlm.nih.gov/pubmed/37416715
http://dx.doi.org/10.1039/d2sc06858c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321483/
https://www.ncbi.nlm.nih.gov/pubmed/37416715
http://dx.doi.org/10.1039/d2sc06858c

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