Suspected Germline TP53 Variants and Clonal Hematopoiesis of Indeterminate Potential: Lessons Learned From a Molecular Tumor Board

OBJECTIVE: Li-Fraumeni syndrome (LFS) is a pan-cancer predisposition syndrome caused by germline pathogenic variants in the gene TP53. The interpretation of TP53 variants in clinical scenarios outside the classic LFS criteria may be challenging. Here, we report a patient affected by 2 primary cancer...

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Detalles Bibliográficos
Autores principales: Xavier, Camila B, Link, Rudinei, Abreu, Leonília, Bettoni, Fabiana, Marson, Fabiane, Galante, Pedro A F, Masotti, Cibele, Amano, Mariane T, de Molla, Vinicius, Camargo, Anamaria A, Asprino, Paula F, Sabbaga, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Precision Medicine Clinic: Molecular Tumor Board
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322129/
https://www.ncbi.nlm.nih.gov/pubmed/37159554
http://dx.doi.org/10.1093/oncolo/oyad105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322129/
https://www.ncbi.nlm.nih.gov/pubmed/37159554
http://dx.doi.org/10.1093/oncolo/oyad105

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