Cargando…
Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway
The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including among pregnant women. Low-calorie sweeteners (LCSs) have increasingly been used as an alternative to sugar to deliver a sweet taste without the excessive caloric load. However, there is little evidence regarding...
Autores principales: | Park, Soyoung, Belfoul, Amine M., Rastelli, Marialetizia, Jang, Alice, Monnoye, Magali, Bae, Hosung, Kamitakahara, Anna, Giavalisco, Patrick, Sun, Shan, Barelle, Pierre-Yves, Plows, Jasmine, Jang, Cholsoon, Fodor, Anthony, Goran, Michael I., Bouret, Sebastien G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322686/ https://www.ncbi.nlm.nih.gov/pubmed/37014702 http://dx.doi.org/10.1172/jci.insight.156397 |
Ejemplares similares
-
Development of the Hypothalamic Melanocortin System
por: Coupe, Berengere, et al.
Publicado: (2013) -
Developmental programming of hypothalamic melanocortin circuits
por: Bouret, Sebastien G.
Publicado: (2022) -
SAT-LB104 Maternal Non-Nutritive Sweeteners Consumption Perturbs Development of Melanocortin Circuits Causing Long-Term Metabolic Alterations in the Offspring
por: Park, Soyoung, et al.
Publicado: (2020) -
Non-nutritive Sweeteners Induce Hypothalamic ER Stress Causing Abnormal Axon Outgrowth
por: Park, Soyoung, et al.
Publicado: (2019) -
Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring
por: Park, Soyoung, et al.
Publicado: (2020)