Heterologous versus homologous boosting elicits qualitatively distinct, BA.5–cross-reactive T cells in transplant recipients

BACKGROUND: The SARS-CoV-2 Omicron BA.5 subvariant escapes vaccination-induced neutralizing antibodies because of mutations in the spike (S) protein. Solid organ transplant recipients (SOTRs) develop high COVID-19 morbidity and poor Omicron variant recognition after COVID-19 vaccination. T cell resp...

Descripción completa

Detalles Bibliográficos
Autores principales: Thompson, Elizabeth A., Ngecu, Wabathi, Stoddart, Laila, Johnston, Trevor S., Chang, Amy, Cascino, Katherine, Alejo, Jennifer L., Abedon, Aura T., Samaha, Hady, Rouphael, Nadine, Tobian, Aaron A.R., Segev, Dorry L., Werbel, William A., Karaba, Andrew H., Blankson, Joel N., Cox, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322695/
https://www.ncbi.nlm.nih.gov/pubmed/37104041
http://dx.doi.org/10.1172/jci.insight.168470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322695/
https://www.ncbi.nlm.nih.gov/pubmed/37104041
http://dx.doi.org/10.1172/jci.insight.168470

Ejemplares similares