In vitro selection of macrocyclic peptide inhibitors containing cyclic γ(2,4)-amino acids targeting the SARS-CoV-2 main protease

γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incorporation of γ-amino acids into peptides is challenging. Here we report how a selection campaign employing a non-canonical peptide library containing cyclic γ(2,4)-amino acids resulted...

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Detalles Bibliográficos
Autores principales: Miura, Takashi, Malla, Tika R., Owen, C. David, Tumber, Anthony, Brewitz, Lennart, McDonough, Michael A., Salah, Eidarus, Terasaka, Naohiro, Katoh, Takayuki, Lukacik, Petra, Strain-Damerell, Claire, Mikolajek, Halina, Walsh, Martin A., Kawamura, Akane, Schofield, Christopher J., Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322702/
https://www.ncbi.nlm.nih.gov/pubmed/37217786
http://dx.doi.org/10.1038/s41557-023-01205-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322702/
https://www.ncbi.nlm.nih.gov/pubmed/37217786
http://dx.doi.org/10.1038/s41557-023-01205-1

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