Epigenetic dysregulation from chromosomal transit in micronuclei

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers(1–4), but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei(5,6) and subsequent rupture of the...

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Detalles Bibliográficos
Autores principales: Agustinus, Albert S., Al-Rawi, Duaa, Dameracharla, Bhargavi, Raviram, Ramya, Jones, Bailey S. C. L., Stransky, Stephanie, Scipioni, Lorenzo, Luebeck, Jens, Di Bona, Melody, Norkunaite, Danguole, Myers, Robert M., Duran, Mercedes, Choi, Seongmin, Weigelt, Britta, Yomtoubian, Shira, McPherson, Andrew, Toufektchan, Eléonore, Keuper, Kristina, Mischel, Paul S., Mittal, Vivek, Shah, Sohrab P., Maciejowski, John, Storchova, Zuzana, Gratton, Enrico, Ly, Peter, Landau, Dan, Bakhoum, Mathieu F., Koche, Richard P., Sidoli, Simone, Bafna, Vineet, David, Yael, Bakhoum, Samuel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322720/
https://www.ncbi.nlm.nih.gov/pubmed/37286593
http://dx.doi.org/10.1038/s41586-023-06084-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322720/
https://www.ncbi.nlm.nih.gov/pubmed/37286593
http://dx.doi.org/10.1038/s41586-023-06084-7

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