Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Mutagenicity testing is an essential component of health safety assessment. Duplex Sequencing (DS), an emerging high-accuracy DNA sequencing technology, may provide substantial advantages over conventional mutagenicity assays. DS could be used to eliminate reliance on standalone reporter assays and...

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Detalles Bibliográficos
Autores principales: Dodge, Annette E., LeBlanc, Danielle P. M., Zhou, Gu, Williams, Andrew, Meier, Matthew J., Van, Phu, Lo, Fang Yin, Valentine III, Charles C., Salk, Jesse J., Yauk, Carole L., Marchetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322784/
https://www.ncbi.nlm.nih.gov/pubmed/37341741
http://dx.doi.org/10.1007/s00204-023-03527-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322784/
https://www.ncbi.nlm.nih.gov/pubmed/37341741
http://dx.doi.org/10.1007/s00204-023-03527-y

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