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Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses

Extrafollicular plasmablast responses (EFRs) are considered to generate antibodies of low affinity that offer little protection from infections. Paradoxically, high avidity antigen-B cell receptor engagement is thought to be the main driver of B cell differentiation, whether in EFRs or slower-develo...

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Detalles Bibliográficos
Autores principales: Lam, Jonathan H., Baumgarth, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322839/
https://www.ncbi.nlm.nih.gov/pubmed/37407556
http://dx.doi.org/10.1038/s41467-023-39734-5