Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier

Study investigators encountered a female Becker muscular dystrophy (BMD) carrier with advanced heart failure (HF) and identified a stop-gain variant in procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) as a potential second-hit variant. Isogenic induced pluripotent stem cells (iPSCs) with d...

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Detalles Bibliográficos
Autores principales: Kameda, Satoshi, Higo, Shuichiro, Shiba, Mikio, Kondo, Takumi, Li, Junjun, Liu, Li, Tabata, Tomoka, Inoue, Hiroyuki, Okuno, Shota, Ogawa, Shou, Kuramoto, Yuki, Yasutake, Hideki, Lee, Jong-Kook, Takashima, Seiji, Ikeda, Yoshihiko, Hikoso, Shungo, Miyagawa, Shigeru, Sakata, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322885/
https://www.ncbi.nlm.nih.gov/pubmed/37426526
http://dx.doi.org/10.1016/j.jacbts.2022.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322885/
https://www.ncbi.nlm.nih.gov/pubmed/37426526
http://dx.doi.org/10.1016/j.jacbts.2022.11.007

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