Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform

Representing the most attractive and successful druggable receptors of the proteome, GPCRs regulate a myriad of physiological and pathophysiological functions. Although over half of present pharmaceuticals target GPCRs, the advancement of drug discovery is hampered by a lack of adequate screening to...

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Detalles Bibliográficos
Autores principales: Zeghal, Manel, Laroche, Geneviève, Freitas, Julia Douglas, Wang, Rebecca, Giguère, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322906/
https://www.ncbi.nlm.nih.gov/pubmed/37407564
http://dx.doi.org/10.1038/s41467-023-39132-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322906/
https://www.ncbi.nlm.nih.gov/pubmed/37407564
http://dx.doi.org/10.1038/s41467-023-39132-x

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