Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from individuals with diabetes and acts as...

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Detalles Bibliográficos
Autores principales: Urizar, Adriana Ibarra, Prause, Michala, Ingerslev, Lars Roed, Wortham, Matthew, Sui, Yinghui, Sander, Maike, Williams, Kristine, Barrès, Romain, Larsen, Martin R., Christensen, Gitte Lund, Billestrup, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322916/
https://www.ncbi.nlm.nih.gov/pubmed/37407581
http://dx.doi.org/10.1038/s41419-023-05906-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322916/
https://www.ncbi.nlm.nih.gov/pubmed/37407581
http://dx.doi.org/10.1038/s41419-023-05906-w

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